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M94A0287.TXT
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1994-10-08
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Document 0287
DOCN M94A0287
TI Human T-cell leukemia virus type I Tax protein represses gene expression
through the basic helix-loop-helix family of transcription factors.
DT 9412
AU Uittenbogaard MN; Armstrong AP; Chiaramello A; Nyborg JK; Department of
Microbiology, Colorado State University, Fort; Collins 80523.
SO J Biol Chem. 1994 Sep 9;269(36):22466-9. Unique Identifier : AIDSLINE
MED/94357879
AB The human T-cell leukemia virus type I (HTLV-I) oncoprotein Tax is a
potent activator of viral and cellular gene transcription. Tax does not
bind DNA directly but utilizes cellular transcription factors to mediate
activation. In this report, we examine the role of the basic
helix-loop-helix (bHLH) proteins in Tax deregulation of gene expression,
as these proteins play a critical role in progression through the cell
cycle and have been implicated in neoplastic disease. We show that the
bHLH proteins do not mediate activation, but instead mediate repression
of gene expression in the presence of Tax. We further show that a
consensus bHLH binding site in the promoter of the beta-polymerase gene,
which encodes an enzyme involved in DNA repair, mediates the previously
reported repression of beta-polymerase gene expression by Tax. Together,
these results suggest that Tax may induce malignant transformation, at
least in part, through bHLH-mediated repression of key cellular
regulatory genes.
DE Animal Base Sequence Binding Sites Cell Line Cercopithecus aethiops
Chloramphenicol Acetyltransferase/BIOSYNTHESIS Consensus Sequence
DNA-Binding Proteins/*METABOLISM *Gene Expression Regulation, Viral
Gene Products, tax/*METABOLISM *Helix-Loop-Helix Motifs
HTLV-I/GENETICS/*METABOLISM Kinetics Molecular Sequence Data
Oligodeoxyribonucleotides Plasmids Support, Non-U.S. Gov't Support,
U.S. Gov't, P.H.S. Transcription Factors/*METABOLISM Transfection
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).